At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
A Preliminary Study of Dexamethasone for Dyspnea in Cancer Patients
In Brief
A Phase 2 clinical trial evaluating Dexamethasone, Placebo, and 3 other interventions for Advanced Cancers and 2 related conditions. Completed, enrolled 52 participants across 1 site.
Detailed Summary
The goal of this clinical research study is to learn if dexamethasone can help reduce shortness of breath in cancer patients. Researchers also want to learn if it can help to improve lung function and quality of life. In this study, dexamethasone will be compared to a placebo. Dexamethasone is commonly used for treatment of nausea, tiredness, and pain. It may help patients with shortness of breath. A placebo is not a drug. It looks like the study drug but is not designed to treat any disease or illness. It is designed to be compared with a study drug to learn if the study drug has any real effect.
Study Details
Timeline
Interventions
Group 1 Blinded Phase: 8 mg (2 capsules of 4 mg) given orally twice a day for 4 days, then 4 mg given orally twice a day for 3 days. Open Label Phase Groups 1 and 2: 4 mg by mouth twice a day for 7 days.
Group 2 Blinded Phase: Two capsules by mouth twice a day for 4 days, followed by one capsule twice a day for 3 days.
Questionnaires completed at baseline and at day 7 and 14. It should take about 15 minutes to complete these questionnaires.
Patient to blow into spirometry machine 1 time a day to test lung function.
Patient called by phone 1 time each day to ask about level of shortness of breath and to remind patient to take capsules. These calls should last about 5 minutes.