At a glance
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A Novel "Pediatric-Inspired" Regimen With Reduced Myelosuppressive Drugs for Adults (Aged 18-60) With Newly Diagnosed Ph Negative Acute Lymphoblastic Leukemia
In Brief
A Phase 2 clinical trial evaluating Daunorubicin, Vincristine, and 10 other interventions for Leukemia. Active but no longer recruiting, targeting 39 participants across 3 sites.
Detailed Summary
The purpose of the study is to find out whether the combination of chemotherapy drugs that are routinely used in children with ALL, will be safe and effective in treating adult patients with ALL. The standard treatment for adults with ALL consists of many chemotherapy drugs that are given in different combinations and in several steps. In adult ALL there is no standard which drugs to give and how to combine them. Some leukemias have a chromosome abnormality called Philadelphia chromosome (also called Ph Positive) and some leukemias do not (called Ph Negative). In this study we want to see whether this combination of chemotherapy drugs will be safe and effective in treating adult patients with Ph Negative ALL.
Study Details
Timeline
Interventions
In the event of a shortage of daunorubicin, doxorubicin may be used as a substitute.
PET or CT scan every 6 months for 3 years