CI

At a glance

ClinicalIndex Comparison Record
Early Ph 1Completed· 80 enrolled
Drug / intervention
Indomethacin +1 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT02653638
NCT02653638Early Ph 1Completed
CompareCT.gov

Cerebral Vasodilator Responses in Sedentary and Exercise Trained Humans

University of Wisconsin, Madison·interventional·Posted Jan 12, 2016·Updated Dec 18, 2019

In Brief

A Early Phase 1 clinical trial evaluating Control and Indomethacin for Cerebrovascular Circulation. Completed, enrolled 80 participants across 1 site.

Detailed Summary

Cerebral vasodilator responses to CO2 will be measured in young healthy adults, healthy sedentary older adults, and healthy exercise trained older adults. This variable will be examined before and after administering the cyclooxygenase inhibitor indomethacin, which has been shown to blunt cerebral vasodilator responses. In addition, the investigators will examine these counter-regulatory hemodynamic mechanisms to hypoperfusion caused by indomethacin.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsCerebrovascular Circulation
CountriesUnited States
CollaboratorsNational Institutes of Health (NIH), National Heart, Lung, and Blood Institute (NHLBI)

Timeline

Early Ph 1CompletedFinished
20162017201820192020202120222023202420252026
First PostedJan 12, 2016
Enrollment StartJun 1, 2016
Primary CompletionApr 1, 2019
TodayJul 1, 2026
Enrollment to primary: 2.8 yearsPosted 10.5 years ago

Interventions

Controlother

1. Transcranial Doppler 2. Blood Pressure 3. Heart Rate 4. Oxygen Saturation

Indomethacindrug

1. Transcranial Doppler 2. Blood Pressure 3. Heart Rate 4. Oxygen Saturation