At a glance
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Phase II Study of the Sequential Combination of Low-Intensity Chemotherapy and Ponatinib Followed by Blinatumomab and Ponatinib in Patients With Philadelphia Chromosome (Ph)-Positive and/or BCR-ABL Positive Acute Lymphoblastic Leukemia (ALL)
In Brief
A Phase 2 clinical trial evaluating Blinatumomab, Cyclophosphamide, and 7 other interventions for Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive and 5 related conditions. Active but no longer recruiting, targeting 22 participants across 1 site.
Detailed Summary
This phase II trial studies how well low-intensity chemotherapy and ponatinib work in treating patients with Philadelphia chromosome-positive and/or BCR-ABL positive acute lymphoblastic leukemia that may have come back or is not responding to treatment. Drugs used in chemotherapy, such as cyclophosphamide, vincristine, dexamethasone, methotrexate, and cytarabine, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Immunotherapy with rituximab and blinatumomab, may induce changes in body's immune system and may interfere with the ability of cancer cells to grow and spread. Ponatinib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Granulocyte colony stimulating factor helps the bone marrow make recover after treatment. Giving low-intensity chemotherapy, ponatinib, and blinatumomab may work better in treating patients with acute lymphoblastic leukemia.
Study Details
Timeline
Interventions
Given via central catheter
Given IV
Given intrathecally or IV
Given SC
Given intrathecally or IV
Given SC
Given PO
Given IV
Given IV