CI

At a glance

ClinicalIndex Comparison Record
Phase 2Active· 135 enrolled / 135 target
Drug / intervention
Dexamethasone +2 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03367156
NCT03367156Phase 2ActiveUpdate Overdue (1.3/mo)Completion was 61mo ago

A Randomized Controlled Trial of Dexamethasone for Dyspnea in Cancer Patients

M.D. Anderson Cancer Center·interventional·Posted Dec 8, 2017·Updated Jun 11, 2026

In Brief

A Phase 2 clinical trial evaluating Dexamethasone, Placebo, and 1 other intervention for Dyspnea and Malignant Neoplasm. Active but no longer recruiting, targeting 135 participants across 3 sites.

Signals

Enrollment appears stalled

Detailed Summary

This phase II trial studies how well dexamethasone works in controlling dyspnea in patients with cancer. Dexamethasone may help control dyspnea (shortness of breath) and improve lung function and quality of life in cancer patients.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States

Timeline

Phase 2Active
201820192020202120222023202420252026202720282029
First PostedDec 8, 2017
Enrollment StartDec 4, 2017
Primary CompletionMay 5, 2021
Study CompletionDec 31, 2028
TodayJul 1, 2026
Enrollment to primary: 3.4 yearsPosted 8.6 years ago

Arms & Interventions

Group I (dexamethasone)experimental

Patients receive dexamethasone PO BID on days 1-28 in the absence of disease progression or unacceptable toxicity.

Drug: DexamethasoneOther: Questionnaire Administration
Group II (placebo, dexamethasone)active_comparator

Patients receive placebo PO BID on days 1-14 and dexamethasone PO BID on days 15-28 in the absence of disease progression or unacceptable toxicity.

Drug: DexamethasoneOther: PlaceboOther: Questionnaire Administration

Interventions

Dexamethasonedrug

Given PO

Placeboother

Given PO

Questionnaire Administrationother

Ancillary studies