CI

At a glance

ClinicalIndex Comparison Record
Phase 3Active· 212 enrolled
Drug / intervention
Methylphenidate +5 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03525873
NCT03525873Phase 3Active

A Study of Cancer Related Fatigue in Patients With Metastatic Cancer Receiving Anti-PD1 Immunotherapy

M.D. Anderson Cancer Center·interventional·Posted May 16, 2018·Updated Apr 15, 2026

In Brief

A Phase 3 clinical trial evaluating Laboratory Biomarker Analysis, Methylphenidate, and 4 other interventions for Advanced Malignant Neoplasm and 2 related conditions. Active but no longer recruiting, targeting 212 participants across 1 site.

Detailed Summary

This phase III trial studies how well methylphenidate and physical activity works in reducing cancer-related fatigue in patients who are receiving anti-PD1 immunotherapy for cancer that has spread to other places in the body. Central nervous systems stimulants, such as methylphenidate, may help to improve cognitive function. Physical activity uses techniques, such as aerobic and resistance exercises, which may help to improve quality of life. Giving methylphenidate and physical activity may help in reducing cancer-related fatigue in patients with metastatic cancer who receive anti-PD1 immunotherapy.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States

Timeline

Phase 3Active
201920202021202220232024202520262027
First PostedMay 16, 2018
Enrollment StartAug 2, 2018
Primary CompletionDec 31, 2026
TodayJul 1, 2026
Enrollment to primary: 8.4 yearsPosted 8.1 years agoPrimary completion in 6 months

Interventions

Laboratory Biomarker Analysisother

Correlative studies

Methylphenidatedrug

Given PO

Physical Activityother

Participate in physical activity

Placeboother

Given PO

Quality-of-Life Assessmentother

Ancillary studies

Questionnaire Administrationother

Ancillary studies