CI

At a glance

ClinicalIndex Comparison Record
Phase 2Active· 99 enrolled
Drug / intervention
Dexamethasone +2 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03583255
NCT03583255Phase 2Active
CompareCT.gov

A Combination Therapy for Cancer-Related Fatigue in Advanced Cancer Patients

M.D. Anderson Cancer Center·interventional·Posted Jul 11, 2018·Updated Dec 26, 2025

In Brief

A Phase 2 clinical trial evaluating Dexamethasone, Exercise Intervention, and 1 other intervention for Advanced Malignant Solid Neoplasm and 4 related conditions. Active but no longer recruiting, targeting 99 participants across 1 site.

Detailed Summary

This phase II/III trial studies how well physical activity with or without dexamethasone works in reducing cancer-related fatigue in patients with cancer that has spread to other places in the body or has come back. Dexamethasone may decrease the body's immune response. Combining physical activity with dexamethasone may help to treat fatigue in patients with cancer.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsAdvanced Malignant Solid Neoplasm, Hematopoietic and Lymphoid System Neoplasm, Locally Advanced Malignant Solid Neoplasm, Metastatic Malignant Solid Neoplasm, Recurrent Malignant Solid Neoplasm
CountriesUnited States
CollaboratorsNational Institute of Nursing Research (NINR)

Timeline

Phase 2Active
2019202020212022202320242025202620272028
First PostedJul 11, 2018
Enrollment StartJun 29, 2018
Primary CompletionDec 31, 2027
TodayJul 1, 2026
Enrollment to primary: 9.5 yearsPosted 8.0 years agoPrimary completion in 1.5 years

Interventions

Dexamethasonedrug

Given PO

Exercise Interventionbehavioral

Complete resistance training and moderate intensity walking

Placebo Administrationother

Given PO