CI

At a glance

ClinicalIndex Comparison Record
N/AUnknown· 429 target
Drug / intervention
Coronary CT angiographyother
Likely dose
Not stated in record
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Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03591328
NCT03591328N/AUnknown
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Exploring the Mechanism of Plaque Rupture in Acute Coronary Syndrome Using Coronary CT Angiography and Computational Fluid Dynamics II (EMERALD II) Study

Seoul National University Hospital·observational·Posted Jul 19, 2018·Updated Aug 23, 2022

In Brief

An observational study evaluating Coronary CT angiography for Acute Myocardial Infarction and Unstable Angina. Targeting 429 participants across 1 site.

Detailed Summary

The EMERALD II study is a multinational, multicenter, and retrospective study. ACS patients who underwent CCTA from 1 months to 3 years prior to the event will be retrospectively identified. Plaques in the non-culprit vessels will be regarded as a primary control group.

Study Details

Study Typeobservational
Allocation--
Masking--
Primary Purpose--
ConditionsAcute Myocardial Infarction, Unstable Angina
CountriesSouth Korea
CollaboratorsInje University Ilsan Paik Hospital, St. Mary's hostpital, Odense University Hospital, University of Milan, Imperial College London, Aarhus University Hospital, Semmelweis University, Oxford University Hospitals NHS Trust, Emory University, Ehime University Graduate School of Medicine, Gifu Heart Center, Wakayama Medical University, Keimyung University Dongsan Medical Center, Seoul National University Bundang Hospital, Seoul National University Hospital Healthcare System Gangnam Center, Chosun University Hospital, Chungnam National University Hospital, Monzino Cardiology Center, OLV Hospital, Monash Heart, University of British Columbia, MOUNT SINAI HOSPITAL, Tokyo Medical University Hachioji Medical Center, Tokai University, St. Luke's International Hospital, Aichi Medical University, Toyohashi Heart Center, Kobe University Hospital, National Cerebral and Cardiovascular Center, Japan, Shin Koga Hospital, Saiseikai Kumamoto Hospital, Tsuchiura Kyodo Hospital, Tokyo Medical Dental University, Loyola University, Leiden University, Weil Cornell Medical College, West Penn Allegheny Health System, Ulsan Hospital, Ulsan University Hospital

Timeline

N/AUnknownOverdue
20192020202120222023202420252026
First PostedJul 19, 2018
Enrollment StartJul 9, 2018
Primary CompletionSep 30, 2022
Study CompletionDec 31, 2022
TodayJul 1, 2026
Enrollment to primary: 4.2 yearsPosted 8.0 years ago

Interventions

Coronary CT angiographyother

Comprehensive CCTA analysis of all culprit and non-culprit lesions to obtain their per-lesion and per-vessel quantitative, qualitative plaque, and hemodynamic features is performed by the independent core laboratory (HeartFlow, Mountain View, CA, USA) blinded to patient characteristics and ICA findings. The current CCTA reporting variables, including % diameter stenosis, segment involvement score (SIS), and HRP features, are obtained for all lesions by another independent core laboratory (University of British Columbia, Vancouver, Canada) to construct a reference model. ICA and invasive imaging studies performed at the event of ACS are analyzed by the independent core laboratory (Samsung Medical Center, Seoul, Korea) to define the culprit lesion blinded to CCTA findings. Other independent experts match culprit and non-culprit lesion data between ICA and CCTA findings.