CI

At a glance

ClinicalIndex Comparison Record
Phase 4Completed· 53 enrolled
Drug / intervention
Mometasone Furoate Nasal Irrigation +1 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03705793
NCT03705793Phase 4Completed
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Effectiveness of Mometasone Nasal Irrigation for Chronic Rhinosinusitis

Washington University School of Medicine·interventional·Posted Oct 15, 2018·Updated Jun 26, 2025

In Brief

A Phase 4 clinical trial evaluating Mometasone Furoate Nasal Irrigation and Mometasone Nasal Spray for Chronic Rhinosinusitis (Diagnosis) and 2 related conditions. Completed, enrolled 53 participants across 2 sites.

Detailed Summary

Chronic rhinosinusitis (CRS) affects up to 12.5% of the US population and has a significant disease burden. The recommended medical management of CRS includes large-volume, low-pressure saline lavage, systemic antibiotics, and intranasal corticosteroids (INCS). While the efficacy and safety of INCS are well-established for the long-term management of CRS, penetration of INCS beyond the nasal vestibule and into the paranasal sinuses is limited. The aim of this study is to evaluate the effectiveness of mometasone furoate large-volume, low-pressure nasal irrigation for surgery-naive CRS patients.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsChronic Rhinosinusitis (Diagnosis), Allergic Rhinosinusitis, Chronic Eosinophilic Rhinosinusitis
CountriesUnited States
Collaborators--

Timeline

Phase 4CompletedFinished
20192020202120222023202420252026
First PostedOct 15, 2018
Enrollment StartJan 1, 2019
Primary CompletionFeb 15, 2020
Study CompletionMar 15, 2020
TodayJul 1, 2026
Enrollment to primary: 1.1 yearsPosted 7.7 years ago

Interventions

Mometasone Furoate Nasal Irrigationdrug

Participants will undergo an 8-week treatment course that includes nasal saline irrigation with mometasone powder and placebo nasal spray.

Mometasone Nasal Spraydrug

Participants will undergo an 8-week treatment course that includes placebo saline irrigation with mometasone nasal spray.