CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 364 enrolled
Drug / intervention
S-ketamine +1 moredrug
Likely dose
S-ketamine 0.2 mg/kgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03927378
NCT03927378N/ACompleted
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Effects of Low-dose S-Ketamine on Incidence of Postpartum Depression in Parturients With Prenatal Depression: A Randomized, Double-blind, Placebo-controlled Trial

Peking University First Hospital·interventional·Posted Apr 25, 2019·Updated Apr 4, 2023

In Brief

A clinical study evaluating S-ketamine and Placebo for Prenatal Depression and 2 related conditions. Completed, enrolled 364 participants across 7 sites.

Detailed Summary

Prenatal depression is an important risk factor of postpartum depression. Low-dose ketamine has been used for depression treatment. As a stereoisomer of ketamine, s-ketamine has similar effects to ketamine in anti-depression. We speculate that, for pregnant women with prenatal depression, low-dose s-ketamine infusion after childbirth may reduce the incidence of postpartum depression.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsPrenatal Depression, Ketamine, Postpartum Depression
CountriesChina
CollaboratorsPeking University International Hospital, Hunan Provincial Maternal and Child Health Care Hospital, Nanjing Medical University, Women's Hospital School Of Medicine Zhejiang University

Timeline

N/ACompletedFinished
2020202120222023202420252026
First PostedApr 25, 2019
Enrollment StartJun 19, 2020
Primary CompletionAug 3, 2022
TodayJul 1, 2026
Enrollment to primary: 2.1 yearsPosted 7.2 years ago

Interventions

S-ketaminedrug

S-ketamine (0.2 mg/kg in 20 ml normal saline) is administered by intravenous infusion in 40 minutes after childbirth.

Placebodrug

Placebo (20 ml normal saline) is administered by intravenous infusion in 40 minutes after childbirth.