At a glance
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Effect of Perioperative Epidural Block and Dexamethasone on Outcome of Patients Undergoing Pancreatic Cancer Surgery: a 2×2 Factorial Randomized Controlled Trial
In Brief
A Phase 4 clinical trial evaluating Epidural block and Dexamethasone for Pancreatic Cancer and 4 related conditions. Active but no longer recruiting, targeting 260 participants across 1 site.
Detailed Summary
Pancreatic cancer remains a devastating disease with an average 5-year survival rate of about 3-5%. Previous retrospective studies showed that perioperative epidural block and/or dexamethasone are associated with improved outcome after cancer surgery. This randomized trial aims to investigate the effect of perioperative epidural block and/or dexamethasone on long-term survival in patients following pancreatic cancer surgery.
Study Details
Timeline
Interventions
Epidural block (with 0.375% ropivacaine) is performed during surgery. Patient-controlled epidural analgesia (with a mixture of 0.12% ropivacaine and 0.5 microgram/ml sufentanyl) is provided after surgery.
Dexamethasone (10 mg) is administered intravenously before anesthesia induction.