At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Changing or Substituting Low-calorie Sweetened Beverages for Sugar-Sweetened Beverages or Water and Cardiometabolic Outcomes: A Systematic Review and Meta-analysis of Prospective Cohort Studies
In Brief
An observational study evaluating Change in LCSBs Intake and Substitute LCSBs for SSBs or Water for Adiposity and 4 related conditions. Targeting 1 participant across 1 site.
Detailed Summary
We propose to conduct a systematic literature review and meta-analysis to assess the association of low-calorie sweetened beverages (LCSBs) on cardiometabolic outcomes in prospective cohort studies. We will be using methodological approaches (change in LCSBs intake, and/or substitution analysis) that attempt to overcome the issue of reverse causality associated with studies of LCSBs and cardiometabolic disease. Ten cardiometabolic outcomes will be assessed: 1. Global adiposity - body weight 2. Global adiposity - BMI 3. Global adiposity - body fat 4. Abdominal adiposity - waist circumference 5. Overweight/obesity incidence 6. Metabolic syndrome incidence 7. Type 2 diabetes incidence 8. Cardiovascular disease incidence 9. Cardiovascular disease mortality 10. Total mortality
Study Details
Timeline
Interventions
Effect of changing LCSBs intake
Effect of substituting LCSBs for SSBs or Water