CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 364 enrolled
Drug / intervention
S-ketamine +1 moredrug
Likely dose
S-ketamine 0.2 mg/kgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04414943
NCT04414943N/ACompleted
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Effects of Low-dose S-ketamine on the Incidence of Postpartum Depression in Women With Prenatal Depression: a Randomized, Double-blind, Placebo-controlled Trial

Peking University First Hospital·interventional·Posted Jun 4, 2020·Updated Apr 4, 2023

In Brief

A clinical study evaluating S-ketamine and Placebo for Prenatal Depression and 2 related conditions. Completed, enrolled 364 participants across 7 sites.

Detailed Summary

Prenatal depression is an important risk factor of postpartum depression. Low-dose ketamine has been used for depression treatment. As a stereoisomer of ketamine, s-ketamine has similar effects to ketamine in anti-depression. We speculate that, for pregnant women with prenatal depression, low-dose s-ketamine infusion after childbirth may reduce the incidence of postpartum depression.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsPrenatal Depression, Ketamine, Postpartum Depression
CountriesChina
CollaboratorsPeking University International Hospital, Hunan Provincial Maternal and Child Health Care Hospital, Nanjing Medical University, Women's Hospital School Of Medicine Zhejiang University

Timeline

N/ACompletedFinished
202120222023202420252026
First PostedJun 4, 2020
Enrollment StartJun 19, 2020
Primary CompletionAug 3, 2022
TodayJul 1, 2026
Enrollment to primary: 2.1 yearsPosted 6.1 years ago

Interventions

S-ketaminedrug

For women in this group, active drug (s-ketamine 0.2 mg/kg in 20 ml normal saline) will be infused at a rate of 30 ml/h (infusion finished in 40 minutes) after giving birth. They will be monitored for 60 minutes and then sent back to the ward.

Placebodrug

For women in this group, placebo (20 ml normal saline) will be infused at a rate of 30 ml/h (infusion finished in 40 minutes) after giving birth. They will be monitored for 60 minutes and then sent back to the ward.