At a glance
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Effects of Propofol Titration at Different Speeds on Hemodynamics and Stress During General Anesthesia Induction
In Brief
A clinical study evaluating 2mg/kg/min, 1mg/kg/min, and 1 other intervention for Anesthesia, General and Hemodynamics. Completed, enrolled 276 participants across 1 site.
Detailed Summary
Propofol is one of the most widely used anesthetics for its fast onset and quick elimination. The conventional speed of its induction dose often causes severe hemodynamics fluctuations with hypotension and arrhythmia. The recommended dosage on the drug insert comes from group pharmacokinetic studies which does not apply to the specific situation of every patient, so the investigators emphasize individualized medication. The investigators have observed the titration of propofol in general anesthesia induction, and found that the dosage was less and the hemodynamics was becoming more stable. At the same time, the investigators found that the hemodynamics still has obvious fluctuations in the titration of the administration rate recommended in the instructions. The investigators intend to further compare the effects of propofol titration administration at different rates for hemodynamics and stress during the induction period of general anesthesia, and find a safer and more appropriate rate of administration.
Study Details
Timeline
Interventions
titration dosing speeds of propofol at 2mg/kg/min
titration dosing speeds of propofol at 1mg/kg/min
titration dosing speeds of propofol at 0.5mg/kg/min