CI

At a glance

ClinicalIndex Comparison Record
Phase 4Completed· 100 enrolled
Drug / intervention
dexmedetomidine combined with midazolam and remifentanil. +1 moredrug
Likely dose
dexmedetomidine combined with midazolam and remifentanil. 0.03 mg/kgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04753515
NCT04753515Phase 4Completed
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Comparison Between Dexmedetomidine and Propofol for Sedation When Combined With Midazolam and Remifentanil During Awake Endotracheal Intubation: A Randomized Double-blind Controlled Study

Sixth Affiliated Hospital, Sun Yat-sen University·interventional·Posted Feb 15, 2021·Updated Nov 30, 2022

In Brief

A Phase 4 clinical trial evaluating dexmedetomidine combined with midazolam and remifentanil. and propofol combined with midazolam and remifentanil. for Sedation and Intubation. Completed, enrolled 100 participants across 1 site.

Detailed Summary

The purpose of this study is to compare the sedation effect of dexmedetomidine and propofol when they are both combined with midazolam and remifentanil during awake endotracheal intubation.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsSedation, Intubation
CountriesChina
Collaborators--

Timeline

Phase 4CompletedFinished
202120222023202420252026
First PostedFeb 15, 2021
Enrollment StartMar 5, 2021
Primary CompletionMay 1, 2021
TodayJul 1, 2026
Enrollment to primary: 2 monthsPosted 5.4 years ago

Interventions

dexmedetomidine combined with midazolam and remifentanil.drug

Patients in this group will receive a bolus of midazolam 0.03 mg/kg intravenously, and then a loading dose of 0.5 mcg/kg remifentanil and 0.5 mcg/kg dexmedetomidine over 5 min via separate syringe pumps.

propofol combined with midazolam and remifentanil.drug

Patients in this group will receive a bolus of midazolam 0.03 mg/kg intravenously, and then a loading dose of 0.5 mcg/kg remifentanil and 0.33 mg/kg propoful over 5 min via separate syringe pumps.