At a glance
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NCT04829708Phase 3RecruitingMonitorUpdated 62mo ago · Completion was 2mo agoEfficacy and Safety of Prophylactic Cranial Irradiation Versus MRI Surveillance in Patients With Limited-stage Small Cell Lung Cancer Who Achieved Remission After First-line Chemoradiotherapy: a Multicenter Randomized Controlled Phase III Clinical Trial
In Brief
A Phase 3 clinical trial evaluating MRI Surveillance and Prophylactic Cranial Irradiation for Limited Stage Small Cell Lung Cancer. Currently recruiting, targeting 534 participants across 2 sites.
Signals
Detailed Summary
This is a prospective, open,multicenter, randomized controlled phase III clinical trial. In patients with LS-SCLC who achieve remission after first-line chemoradiotherapy, the efficacy and safety of PCI or MRI surveillance is evaluated and analyzed. PCI is performed in hopes of preventing spread of cancer into the brain. The use of brain MRI alone may reduce side effects of receiving PCI and prolong patients' lifespan. MRI surveillance alone (delaying radiation until the actual brain metastasis) may be not inferior to PCI.
Study Details
Timeline
Interventions
Receive MRI surveillance
Receive PCI