CI

At a glance

ClinicalIndex Comparison Record
Phase 1Unknown· 12 enrolled
Drug / intervention
HLX53biological
Likely dose
HLX53 30mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05394168
NCT05394168Phase 1Unknown

A Phase I Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetic Characteristics and Preliminary Efficacy of HLX53 (an Anti-TIGIT Fc Fusion Protein) in Patients With Advanced/Metastatic Solid Tumors

Shanghai Henlius Biotech·interventional·Posted May 27, 2022·Updated Apr 1, 2024

In Brief

A Phase 1 clinical trial evaluating HLX53 for Advanced/Metastatic Solid Tumors. Targeting 12 participants across 1 site.

Detailed Summary

This phase I, first-in-human, open-label clinical study will evaluate the safety, tolerability, pharmacokinetic characteristics and preliminary efficacy of HLX53 (an anti-TIGIT Fc fusion protein) in patients with advanced/metastatic solid tumors.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesChina
Collaborators--

Timeline

Phase 1UnknownOverdue
2023202420252026
First PostedMay 27, 2022
Enrollment StartDec 9, 2022
Primary CompletionDec 4, 2024
Study CompletionMar 4, 2025
TodayJul 1, 2026
Enrollment to primary: 2.0 yearsPosted 4.1 years ago

Interventions

HLX53biological

There are 5 preset dose groups, namely 30mg/QW, 150mg/QW, 400mg/QW, 1000mg/Q3W and 2000mg/Q3W, administered by intravenous infusion.