At a glance
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Comparison of Patient-Reported Outcome and Safety Outcomes Between Preoperative and Postmastectomy Radiotherapy in Breast Cancer Patients with Reconstruction of DIEP Flap: a Multicenter，Prospective，Open-label，Randomized Controlled Trial
In Brief
A clinical study evaluating Preoperative radiotherapy and Postmastectomy radiotherapy for Breast Cancer. Currently recruiting, targeting 80 participants across 6 sites.
Detailed Summary
This study is the first prospective randomized study assessing the patient-reported outcomes and safety outcomes between preoperative and postmastectomy radiotherapy in locally advanced breast cancer patients with immediate reconstruction of deep inferior epigastric perforator(DIEP) flap. Radiotherapy before mastectomy and autologous free-flap breast reconstruction can avoid adverse radiation effects on healthy donor tissues and delays to adjuvant radiotherapy. We aimed to explore the feasibility of preoperative radiotherapy followed by DIEP flap reconstruction in patients with breast cancer requiring mastectomy.
Study Details
Timeline
Interventions
Radiotherapy followed by mastectomy and DIEP flap reconstruction
Radiotherapy after mastectomy and DIEP flap reconstruction