At a glance
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NCT06062550Phase 4ActiveUpdate OverdueUpdated 2mo ago · Completion was 8mo agoEfficacy of Different Dose Esketamine and Dexmedetomidine Combination for Supplemental Analgesia After Scoliosis Correction Surgery: A Randomized, Double-blind Trial
In Brief
A Phase 4 clinical trial evaluating Esketamine for Scoliosis Correction and 4 related conditions. Active but no longer recruiting, targeting 312 participants across 1 site.
Signals
Detailed Summary
Scoliosis correction surgery is associated with severe pain. Patients after scoliosis correction surgery usually require high dose opioids and long duration analgesia, which may increase side effects and drug tolerance. In a recent trial, mini-dose esketamine and dexmedetomidine combination as a supplement to sufentanil significantly improved analgesia and subjective sleep quality after spinal correction surgery without increasing adverse events; however, the proportion of patients with moderate-to-severe pain remained high. The authors speculate that increasing esketamine dose in the combination may further improve analgesic effects.
Study Details
Timeline
Interventions
Different doses of esketamine in the esketamine-dexmedetomidine combination as a supplement to sufentanil for postoperative intravenous analgesia.