At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
A Liquid Biopsy Assay For The Non-Invasive Early Detection of Advanced Adenomas and Colorectal Cancer
In Brief
An observational study evaluating DENEB for Colorectal Cancer and 17 related conditions. Currently recruiting, targeting 2,000 participants across 6 sites in 5 countries.
Detailed Summary
This study aims to develop a highly sensitive, specific, and cost-effective blood assay for early detection of colorectal adenomas and cancer, using advanced machine learning and state-of-the-art biological analyses.
Study Details
Timeline
Arms & Interventions
Individuals who underwent colonoscopy and were found not to have any adenomas or cancer.
Individuals who underwent colonoscopy and were found to only have low-risk adenomas, defined as all of the following: * 1 to 4 adenomas at most. * All adenomas have low-grade dysplasia at most. * All adenomas are \<10 mm in diameter
Individuals who underwent colonoscopy and were found to have high-risk adenomas, defined as one or more of the following: * 5 or more adenomas. * One or more adenomas have high-grade dysplasia. * One or more adenomas are \>10 mm in diameter
Individuals who underwent colonoscopy and were found to have colorectal cancer.
Individuals who underwent colonoscopy and were found not to have any adenomas or cancer.
Individuals who underwent colonoscopy and were found to only have low-risk adenomas, defined as: * 1 to 4 adenomas at most. * All adenomas have low-grade dysplasia at most. * All adenomas are \<10 mm in diameter.
Individuals who underwent colonoscopy and were found to have high-risk adenomas, defined as one or more of the following: * 5 or more adenomas. * One or more adenomas have high-grade dysplasia. * One or more adenomas are \>10 mm in diameter.
Individuals who underwent colonoscopy and were found to have colorectal cancer.
Individuals who underwent colonoscopy and were found not to have any adenomas or cancer.
Individuals who underwent colonoscopy and were found to only have low-risk adenomas, defined as: * 1 to 4 adenomas at most. * All adenomas have low-grade dysplasia at most. * All adenomas are \<10 mm in diameter.
Individuals who underwent colonoscopy and were found to have high-risk adenomas, defined as one or more of the following: * 5 or more adenomas. * One or more adenomas have high-grade dysplasia. * One or more adenomas are \>10 mm in diameter.
Individuals who underwent colonoscopy and were found to have colorectal cancer.
Interventions
A panel of circulating microRNA, whose expression level is tested in cell-free and exosome-derived samples.