CI

At a glance

ClinicalIndex Comparison Record
Phase 2Recruiting· 78 target
Drug / intervention
Olutasidenib +3 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT06445959
NCT06445959Phase 2RecruitingOn Track

Phase 1b/2 Study of Decitabine and Venetoclax in Combination With the Targeted Mutant IDH1 Inhibitor Olutasidenib

M.D. Anderson Cancer Center·interventional·Posted Jun 6, 2024·Updated May 20, 2026

In Brief

A Phase 2 clinical trial evaluating Olutasidenib, Venetoclax, and 2 other interventions for Mutant IDH1 Inhibitor Olutasidenib. Currently recruiting, targeting 78 participants across 3 sites.

Detailed Summary

To find a recommended combination dose of decitabine and venetoclax that can be given in combination with olutasidenib to participants with AML.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States

Timeline

Phase 2Recruiting
20252026202720282029
First PostedJun 6, 2024
Enrollment StartAug 29, 2024
Primary CompletionJun 30, 2027
Study CompletionJun 30, 2029
TodayJul 1, 2026
Enrollment to primary: 2.8 yearsPosted 2.1 years agoPrimary completion in 12 months

Interventions

Olutasidenibdrug

Given by PO

Venetoclaxdrug

Given by PO

Decitabinedrug

Given by IV

Decitabine/cedazuridinedrug

Given by PO