At a glance

ClinicalIndex Comparison Record

Phase 2Recruiting· 130 target

Drug / intervention

Online adaptive SBRT +1 moreradiation

Likely dose

Not stated in record

Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT06542159

NCT06542159Phase 2RecruitingOn TrackUpdated 7mo ago

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Elimination of PTV Margins Based on Online Adaptive Stereotactic Radiotherapy for Early-stage Non-small Cell Lung Cancer or Pulmonary Oligometastases: a Prospective, Randomized, Controlled Phase II Study

Sun Yat-sen University·interventional·Posted Aug 7, 2024·Updated Nov 17, 2025

In Brief

A Phase 2 clinical trial evaluating Online adaptive SBRT and Conventional SBRT for Adaptive Radiotherapy and 4 related conditions. Currently recruiting, targeting 130 participants across 1 site.

Detailed Summary

This study aims to explore the safety and efficacy of eliminating the PTV (planning target volume) margins based on online adaptive stereotactic radiotherapy for patients with early-stage non-small cell lung cancer (NSCLC) or pulmonary oligometastases.

Study Details

Study Typeinterventional

Allocation--

Masking--

Primary Purpose--

ConditionsAdaptive Radiotherapy, Stereotactic Body Radiotherapy, Non-small Cell Lung Cancer, Lung Oligometastases, Toxicity

CountriesChina

Collaborators--

Timeline

Phase 2Recruiting

2025202620272028

Enrollment StartMay 2024

First PostedAug 2024

TodayJul 2026

Primary CompletionApr 2027

Study CompletionApr 2028

First PostedAug 7, 2024

Enrollment StartMay 22, 2024

Primary CompletionApr 21, 2027

Study CompletionApr 21, 2028

TodayJul 1, 2026

Enrollment to primary: 2.9 yearsPosted 1.9 years agoPrimary completion in 10 months

Interventions

Online adaptive SBRTradiation

Online adaptive SBRT (without PTV expansion margin). The total dose will be 45-50Gy/3-4 fractions, administered once daily. FBCT and 4DCT will be acquired.

Conventional SBRTradiation

SBRT with PTV expansion. The total dose will be 45-50Gy/3-4 fractions, administered once daily. CBCT will be acquired.