CI

At a glance

ClinicalIndex Comparison Record
Phase 3Recruiting· 536 target
Drug / intervention
Ivonescimab, docetaxel +1 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT06928389
NCT06928389Phase 3RecruitingOn TrackUpdated 2mo ago

A Randomized, Double-blind, Multicenter Phase 3 Clinical Trial of Ivonescimab Versus Placebo, Combined With Docetaxel in Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer (NSCLC) That Has Progressed on or After PD-(L)1 Inhibitor-based Therapy

Akeso·interventional·Posted Apr 15, 2025·Updated Apr 9, 2026

In Brief

A Phase 3 clinical trial evaluating Ivonescimab, docetaxel and Placebo, docetaxel for Non-Small Cell Lung Cancer. Currently recruiting, targeting 536 participants across 1 site.

Detailed Summary

This is a Phase 3 Randomized, double-blind, Multicenter Study of Ivonescimab Combined with Docetaxel Versus Placebo Combined with Docetaxel in Patients with Locally advanced or Metastatic Non-small Cell Lung Cancer (NSCLC) that has progressed on or after PD-(L)1 inhibitor-based therapy. The purpose of this study is to evaluate the efficacy and safety of ivonescimab versus placebo, combined with docetaxel in patients with advanced NSCLC.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesChina
Collaborators--

Timeline

Phase 3Recruiting
20262027202820292030
First PostedApr 15, 2025
Enrollment StartJul 8, 2025
Primary CompletionMay 1, 2027
Study CompletionJun 1, 2030
TodayJul 1, 2026
Enrollment to primary: 1.8 yearsPosted 1.2 years agoPrimary completion in 10 months

Interventions

Ivonescimab, docetaxeldrug

Patients will receive ivonescimab and docetaxel as an IV injection

Placebo, docetaxeldrug

Patients will receive placebo and docetaxel as an IV injection