CI

At a glance

ClinicalIndex Comparison Record
N/ARecruiting· 70 target
Drug / intervention
MZRWdietary
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT07091084
NCT07091084N/ARecruitingOn Track

Herbal Formula Ma-Zi-Ren-Wan (MZRW) on Bowel Movement Function and Gut Microbiome Among Cancer Survivors With Constipation: A Double-blinded Randomized Controlled Trial (RELIEVE)

Memorial Sloan Kettering Cancer Center·interventional·Posted Jul 29, 2025·Updated May 22, 2026

In Brief

A clinical study evaluating MZRW for Constipation and 2 related conditions. Currently recruiting, targeting 70 participants across 7 sites.

Detailed Summary

The purpose of this study is to find out whether MZRW is an effective treatment for constipation in cancer survivors. The researchers will compare MZRW with placebo, a pill that looks like MZRW and is given in the same way, but contains no medication. The researchers will also study the effect MZRW has on the gut microbiome. The gut microbiome is a diverse community of microorganisms living in the digestive system, essential for digestion and immune function.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States
Collaborators--

Timeline

N/ARecruiting
202620272028
First PostedJul 29, 2025
Enrollment StartJul 15, 2025
Primary CompletionJul 15, 2028
TodayJul 1, 2026
Enrollment to primary: 3 yearsPosted 11 months agoPrimary completion in 2.0 years

Interventions

MZRWdietary

MZRW herbal formula consists of a 7:1 extract of Huo Ma Ren \[Hemp Seed 33.4%\]; Da Huang (Sheng) \[Rhubarb (Fresh) 22.2%\]; Bai Shao \[Peony (White) 11.1%\]; Zhi Shi \[Aurantium Immaturus 11.1%\]; Hou Po \[Magnolia Bark 11.1%\]; and Xing Ren \[Apricot Kernel 11.1%\] - Taken for 2 weeks intervention and 2 weeks follow-up