CI

At a glance

ClinicalIndex Comparison Record
Phase 3Recruiting· 530 target
Drug / intervention
Intra-arterial thrombolysis as adjunct to endovascular treatment +1 morecombination
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT07137832
NCT07137832Phase 3RecruitingOn TrackUpdated 2mo ago
CompareCT.gov

OPtimizing REperfusion by Intra-Arterial ThRomboLysis as Adjunct to Endovascular Treatment for Medium Vessel Occlusion (PEARL-MeVO): A Multicenter, Prospective, Randomized Controlled, Open-label, Blinded-Endpoint Clinical Trial

Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University·interventional·Posted Aug 22, 2025·Updated Apr 16, 2026

In Brief

A Phase 3 clinical trial evaluating Intra-arterial thrombolysis as adjunct to endovascular treatment and Standard medical treatment for Acute Ischemic Stroke. Currently recruiting, targeting 530 participants across 1 site.

Detailed Summary

PEARL-MeVO is an investigator-initiated, multicenter, prospective, randomized controlled, open-label, blinded endpoint (PROBE) clinical trial aiming at evaluating the efficacy and safety of intra-arterial thrombolysis as adjunct to endovascular treatment in improving 90-day functional outcome in acute ischemic stroke patients due to medium vessel occlusion (MeVO) within 24 hours of symptom onset.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsAcute Ischemic Stroke
CountriesChina
Collaborators--

Timeline

Phase 3Recruiting
2026202720282029
First PostedAug 22, 2025
Enrollment StartOct 9, 2025
Primary CompletionDec 31, 2028
TodayJul 1, 2026
Enrollment to primary: 3.2 yearsPosted 10 months agoPrimary completion in 2.5 years

Interventions

Intra-arterial thrombolysis as adjunct to endovascular treatmentcombination

Intra-arterial thrombolysis as adjunct to endovascular treatment, in addition to standard medical treatment

Standard medical treatmentother

Standard medical treatment