CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 535 enrolled
Drug / intervention
Small RNA sequencing +1 moreother
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT07225452
NCT07225452N/ACompleted
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Liquid Biopsy Using Exosomal miRNA for Intrahepatic Cholangiocarcinoma Detection

City of Hope Medical Center·observational·Posted Nov 6, 2025·Updated Mar 13, 2026

In Brief

An observational study evaluating Small RNA sequencing and LUMIC assay for Intrahepatic Cholangiocarcinoma (Icc). Completed, enrolled 535 participants across 1 site.

Detailed Summary

Intrahepatic cholangiocarcinoma (ICC) is a malignant liver tumor with poor prognosis and limited curative treatment options. Early and accurate detection remains an unmet clinical need. The LUMIC study aims to develop a non-invasive liquid biopsy platform based on both exosomal microRNAs (exo-miRNAs) to detect intrahepatic cholangiocarcinoma with high sensitivity and specificity.

Study Details

Study Typeobservational
Allocation--
Masking--
Primary Purpose--
ConditionsIntrahepatic Cholangiocarcinoma (Icc)
CountriesUnited States
Collaborators--

Timeline

N/ACompletedFinished
20252026
First PostedNov 6, 2025
Enrollment StartJun 21, 2024
Primary CompletionJan 5, 2026
Study CompletionFeb 5, 2026
TodayJul 1, 2026
Enrollment to primary: 1.5 yearsPosted 8 months ago

Interventions

Small RNA sequencingother

Small RNA sequencing of serum/plasma RNA to identify ICC-specific upregulated miRNAs

LUMIC assayother

RT-qPCR validation of selected miRNAs